Novel aspects of corneal angiogenic and lymphangiogenic privilege
Identifieur interne : 005730 ( Main/Exploration ); précédent : 005729; suivant : 005731Novel aspects of corneal angiogenic and lymphangiogenic privilege
Auteurs : David Ellenberg [États-Unis] ; Dimitri T. Azar [États-Unis] ; Joelle A. Hallak [États-Unis] ; Faisal Tobaigy [États-Unis] ; Kyu Yeon Han [États-Unis] ; Sandeep Jain [États-Unis] ; Zhongjun Zhou [Hong Kong] ; Jin-Hong Chang [États-Unis]Source :
- Progress in retinal and eye research [ 1350-9462 ] ; 2010.
Abstract
In this article, we provide the results of experimental studies demonstrating that corneal avascularity is an active process involving the production of anti-angiogenic factors, which counterbalance the proangiogenic/lymphangiogenic factors that are upregulated during wound healing. We also summarize pertinent published reports regarding corneal neovascularization (NV), corneal lymphangiogenesis and corneal angiogenic/lymphangiogenic privilege. We outline the clinical causes of corneal NV, and discuss the angiogenic proteins (VEGF and bFGF) and angiogenesis regulatory proteins. We also describe the role of matrix metalloproteinases MMP-2, -7, and MT1-MMP, anti-angiogenic factors, and lymphangiogenic regulatory proteins during corneal wound healing. Established and potential new therapies for the treatment of corneal neovascularization are also discussed.
Url:
DOI: 10.1016/j.preteyeres.2010.01.002
PubMed: 20100589
PubMed Central: 3685179
Affiliations:
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Taylor Street, Chicago, IL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, University of Illinois at Chicago, 1855W. Taylor Street, Chicago, IL</wicri:regionArea><orgName type="university">Université de l'Illinois à Chicago</orgName><placeName><settlement type="city">Chicago</settlement><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Azar, Dimitri T" sort="Azar, Dimitri T" uniqKey="Azar D" first="Dimitri T." last="Azar">Dimitri T. Azar</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, University of Illinois at Chicago, 1855W. Taylor Street, Chicago, IL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, University of Illinois at Chicago, 1855W. Taylor Street, Chicago, IL</wicri:regionArea><orgName type="university">Université de l'Illinois à Chicago</orgName><placeName><settlement type="city">Chicago</settlement><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Hallak, Joelle A" sort="Hallak, Joelle A" uniqKey="Hallak J" first="Joelle A." last="Hallak">Joelle A. Hallak</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, University of Illinois at Chicago, 1855W. Taylor Street, Chicago, IL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, University of Illinois at Chicago, 1855W. Taylor Street, Chicago, IL</wicri:regionArea><orgName type="university">Université de l'Illinois à Chicago</orgName><placeName><settlement type="city">Chicago</settlement><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Tobaigy, Faisal" sort="Tobaigy, Faisal" uniqKey="Tobaigy F" first="Faisal" last="Tobaigy">Faisal Tobaigy</name><affiliation wicri:level="1"><nlm:aff id="A2">Department of Ophthalmology, Harvard Medical School, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, Harvard Medical School, Boston, MA</wicri:regionArea><wicri:noRegion>MA</wicri:noRegion></affiliation></author><author><name sortKey="Han, Kyu Yeon" sort="Han, Kyu Yeon" uniqKey="Han K" first="Kyu Yeon" last="Han">Kyu Yeon Han</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, University of Illinois at Chicago, 1855W. Taylor Street, Chicago, IL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, University of Illinois at Chicago, 1855W. Taylor Street, Chicago, IL</wicri:regionArea><orgName type="university">Université de l'Illinois à Chicago</orgName><placeName><settlement type="city">Chicago</settlement><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Jain, Sandeep" sort="Jain, Sandeep" uniqKey="Jain S" first="Sandeep" last="Jain">Sandeep Jain</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, University of Illinois at Chicago, 1855W. Taylor Street, Chicago, IL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, University of Illinois at Chicago, 1855W. Taylor Street, Chicago, IL</wicri:regionArea><orgName type="university">Université de l'Illinois à Chicago</orgName><placeName><settlement type="city">Chicago</settlement><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Zhou, Zhongjun" sort="Zhou, Zhongjun" uniqKey="Zhou Z" first="Zhongjun" last="Zhou">Zhongjun Zhou</name><affiliation wicri:level="1"><nlm:aff id="A3">Department of Biochemistry, The University of Hong Kong, Hong Kong</nlm:aff><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Department of Biochemistry, The University of Hong Kong</wicri:regionArea><wicri:noRegion>The University of Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Chang, Jin Hong" sort="Chang, Jin Hong" uniqKey="Chang J" first="Jin-Hong" last="Chang">Jin-Hong Chang</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, University of Illinois at Chicago, 1855W. Taylor Street, Chicago, IL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, University of Illinois at Chicago, 1855W. Taylor Street, Chicago, IL</wicri:regionArea><orgName type="university">Université de l'Illinois à Chicago</orgName><placeName><settlement type="city">Chicago</settlement><region type="state">Illinois</region></placeName></affiliation></author></analytic><series><title level="j">Progress in retinal and eye research</title><idno type="ISSN">1350-9462</idno><idno type="eISSN">1873-1635</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">In this article, we provide the results of experimental studies demonstrating that corneal avascularity is an active process involving the production of anti-angiogenic factors, which counterbalance the proangiogenic/lymphangiogenic factors that are upregulated during wound healing. We also summarize pertinent published reports regarding corneal neovascularization (NV), corneal lymphangiogenesis and corneal angiogenic/lymphangiogenic privilege. We outline the clinical causes of corneal NV, and discuss the angiogenic proteins (VEGF and bFGF) and angiogenesis regulatory proteins. We also describe the role of matrix metalloproteinases MMP-2, -7, and MT1-MMP, anti-angiogenic factors, and lymphangiogenic regulatory proteins during corneal wound healing. Established and potential new therapies for the treatment of corneal neovascularization are also discussed.</p></div></front></TEI><affiliations><list><country><li>Hong Kong</li><li>États-Unis</li></country><region><li>Illinois</li></region><settlement><li>Chicago</li></settlement><orgName><li>Université de l'Illinois à Chicago</li></orgName></list><tree><country name="États-Unis"><region name="Illinois"><name sortKey="Ellenberg, David" sort="Ellenberg, David" uniqKey="Ellenberg D" first="David" last="Ellenberg">David Ellenberg</name></region><name sortKey="Azar, Dimitri T" sort="Azar, Dimitri T" uniqKey="Azar D" first="Dimitri T." last="Azar">Dimitri T. Azar</name><name sortKey="Chang, Jin Hong" sort="Chang, Jin Hong" uniqKey="Chang J" first="Jin-Hong" last="Chang">Jin-Hong Chang</name><name sortKey="Hallak, Joelle A" sort="Hallak, Joelle A" uniqKey="Hallak J" first="Joelle A." last="Hallak">Joelle A. Hallak</name><name sortKey="Han, Kyu Yeon" sort="Han, Kyu Yeon" uniqKey="Han K" first="Kyu Yeon" last="Han">Kyu Yeon Han</name><name sortKey="Jain, Sandeep" sort="Jain, Sandeep" uniqKey="Jain S" first="Sandeep" last="Jain">Sandeep Jain</name><name sortKey="Tobaigy, Faisal" sort="Tobaigy, Faisal" uniqKey="Tobaigy F" first="Faisal" last="Tobaigy">Faisal Tobaigy</name></country><country name="Hong Kong"><noRegion><name sortKey="Zhou, Zhongjun" sort="Zhou, Zhongjun" uniqKey="Zhou Z" first="Zhongjun" last="Zhou">Zhongjun Zhou</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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